FREMGANGSMADE TIL FREMSTILLING AF 2-SUBSTITUEREDE OXAZOLPYRIDINER
- 申请公布号：
- DK320276(A)
- 申请号：
- DK19760003202
- 申请日期：
- 1976.07.15
- 申请公布日期：
- 1977.01.30
- 申请人：
- MERCK & CO INC.
- 发明人：
- JENSEN N P
- 分类号：
- A61K31/435;A61P17/00;A61P29/00;C07C63/72;C07C205/57;C07D213/73;C07D498/04;(IPC1-7):C07D/
- 主分类号：
- A61K31/435
- 摘要：
- 1497985 Oxazolo[4,5-b]pyridines MERCK & CO Inc 26 July 1976 [29 July 1975] 31065/76 Heading C2C The invention comprises compounds of formula wherein R is H, halogen or C 1-5 alkyl or alkoxy, R<SP>1</SP> is H or C 1-5 alkyl, and n is 3, 4 or 5. In examples, these compounds are prepared by (a) condensing a corresponding 2-amino-3-hydroxypyridine with an appropriate indone-tetrahydronaphthalene- or benzocycloheptene-derived carboxylic acid, or (b) forming the analogue in which R is OH by splitting the methyl ether (R = OMe), followed by etherification to give a different ether. Starting materials otherwise prepared are amino- and nitro-indane (or tetrahydronaphthalene) carboxylic acids. Therapeutic compositions having antiinflammatory activity comprise compounds of the above formula, and may be administered topically.
Copyright Notice © 2009-2024 传众 版权所有