METHOD OF MANUFACTURING THE CYCLOHEPTIMIDAZOLE DERIVATIVES
- 申请公布号:
- HU9502172(D0)
- 申请号:
- HU19950002172
- 申请日期:
- 1995.07.19
- 申请公布日期:
- 1995.09.28
- 申请人:
- KOTOBUKI SEIYAKU CO.,LTD.
- 发明人:
- TOMIYAMA,TSUYOSHI;YANAGISAWA,TAKASHI;TOMIYAMA,AKIRA
- 分类号:
- A61K31/415;A61P9/00;A61P9/12;A61P43/00;C07D235/02;C07D403/10
- 主分类号:
- A61K31/415
- 摘要:
- <p>Disclosed is a method in which a compound of general formula (1) is reacted with a compound of general formula (2), followed by deprotection of protective group Z to give the cycloheptimidazole derivative (4) wherein R1 is hydrogen or isopropyl; R2 is a lower alkyl; A and A1 are each a substituent at the 4- or 8-position, A1 is hydrogen or hydroxyl when A is a hydrogen or A and A1 together form an oxo group or =CHCOOR3 (R3 represents a lower alkyl); the dotted line means two double bonds or saturated single bonds; X is halogen atom or trifluoromethanesulfonate group; Y is B (OH) 2 or -Sn (R5) 3 (R5 represents a lower alkyl group). The cycloheptimidazole derivative (4) is useful as antihypertensive agent. ( 1 ) (2) (4) </p>
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