Indol derivatives, the method for preparing thereof and composition for the prevention and treatment of metabolic disorder containing the same as an active ingredient
- 申请公布号：
- US7902190(B2)
- 申请号：
- US20070442930
- 申请日期：
- 2007.09.27
- 申请公布日期：
- 2011.03.08
- 申请人：
- KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- 发明人：
- LEE KYEONG;LEE HYUN SUN;LEE JUNG JOON;KIM YOUNG KOOK;RHO MUN-CHUAL;LEE JEONG HYUNG;PARK HYE-RAN;LEE CHUL-HO;CHOI YONGSEOK
- 分类号：
- A61K31/535
- 主分类号：
- A61K31/535
- 摘要：
- Disclosed are indole derivatives, a preparation method thereof, and a composition for the prevention and treatment of metabolic diseases, containing the same as an active ingredient. The indole derivatives have inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, the composition is thus useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
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