PREPARATION OF ADIPIC ACID

申请公布号：

US2012028320(A1)

申请号：

US201013255473

申请日期：

2010.03.11

申请公布日期：

2012.02.02

申请人：

RAEMAKERS-FRANKEN PETRONELLA CATHARINA;SCHUERMANN MARTIN;TREFZER AXEL CHRISTOPH;DE WILDEMAN STEFAAN MARIE ANDRE;DSM IP ASSETS B.V.

发明人：

RAEMAKERS-FRANKEN PETRONELLA CATHARINA;SCHUERMANN MARTIN;TREFZER AXEL CHRISTOPH;DE WILDEMAN STEFAAN MARIE ANDRE

分类号：

C12P7/44;C12N1/15;C12N1/19;C12N1/21;C12P7/62

主分类号：

C12P7/44

摘要：

The invention relates to a method for preparing adipic acid, comprising converting alpha-ketoglutaric acid (AKG) into alpha-ketoadipic acid (AKA), converting alpha-ketoadipic acid into alpha-ketopimelic acid (AKP), converting alpha-ketopimelic acid into 5-formylpentanoic acid (5-FVA), and converting 5-formylpentanoic acid into adipic acid, wherein at least one of these conversions is carried out using a heterologous biocatalyst.The invention further relates to a heterologous cell, comprising one or more heterologous nucleic acid sequences encoding one or more heterologous enzymes capable of catalysing at least one reaction step in said method.