PROCESS FOR PREPARING 1-(TETRAHYDRO-2-FURANYL)-5-FLUOROURACH
- 申请公布号：
- IL47033(A)
- 申请号：
- IL19750047033
- 申请日期：
- 1975.04.07
- 申请公布日期：
- 1978.06.15
- 申请人：
- UNIVERSITY OF UTAH
- 分类号：
- C07D405/04;(IPC1-7):07D405/04
- 主分类号：
- C07D405/04
- 摘要：
- <p>An improved method for synthesizing 1-(tetrahydro - 2-furanyl) - 5-fluorouracil from a silyl derivitive of 5-fluorouracil (bis - trimethylsilyl 5-fluorouracil) by reacting the same with 2-chlorotetrahydrofuran. The reaction is carried out at controlled conditions of temperature and under an inert gas. Yields in excess of 80% of the theoretical are obtained as calculated upon the starting amounts of 5-fluorouracil.</p>
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