A RECOMBINANT HUMAN FACTOR VIII DERIVATIVE
- 申请公布号:
- WO1991009122(A1)
- 申请号:
- SE1990000809
- 申请日期:
- 1990.12.06
- 申请公布日期:
- 1991.06.27
- 摘要:
- <p>A DNA sequence coding for a biologically active recombinant human factor VIII derivative, comprising a first DNA segment coding for the 90 kDa chain of human factor VIII and a second DNA segment coding for the 80 kDa chain of human factor VIII, said segments being interconnected by a linker DNA segment coding for a linker peptide of 4 to about 100 amino acid residues of the B domain of human factor VIII, at least 4 of said amino acid residues originating from the C terminal of said domain; recombinant expression vector comprising such DNA sequence; host cells of animal origin transformed with such recombinant expression vector; a process for the manufacture of recombinant human factor VIII derivative; and human factor VIII derivative containing the heavy chain and the light chain linked by metal ion bond.</p>
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