POLYSTYRENE POLYMERS AND THEIR USE AS CHOLESTEROL LOWERING AGENTS
- 申请公布号:
- ZA9003896(B)
- 申请号:
- ZA19900003896
- 申请日期:
- 1990.05.21
- 申请公布日期:
- 1991.12.24
- 申请人:
- SMITH KLINE & FRENCH LABORATORIES LIMITED
- 发明人:
- ALBERT ANDRZEJ JAXA-CHAMIEC;DEIDRE MARY BERNADETTE HICKEY;VIRENDRA PREMCHAND SHAH
- 分类号:
- A61K31/785;A61P3/06;B01J41/14;C08F8/44;C08F212/00
- 主分类号:
- A61K31/785
- 摘要:
- Polymers of structure : <CHEM> in which X is CH2, CO or CHOH; Z is H or a group X(CH2)nN/<+>R<1>R<2>R<3>; n is 1 to 20; R<1> and R<2> are the same or different and are each C1-4alkyl; R<3> is C1-20alkyl; or R<1>, R<2> and R<3> together with the nitrogen atom to which they are attached form a ring, optionally containing one or more further heteroatoms, and optionally being substituted with a C1-4alkyl group; a, b and c are numbers which indicate the relative molar percentages of the units present in a random distribution in said polymer, (b) being from about 0.5 to about 10 molar percent, and (c) being from about 30 to about 99 molar percent; m is a number indicating the degree of polymerization of said polymer, and Y<-> is a physiologically acceptable counter ion, processes for their preparation, pharmaceutical compositions containing them and their use in therapy as anti-hyperchloesterolaemic agents.
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