SUBSTITUTED N-(QUINOLIN-2-YL-METHOXY) BENZYL-SULPHONYLUREA LEUKOTRIENE SYNTHESIS INHIBITORS
- 申请公布号:
- US5179106(A)
- 申请号:
- US19900558730
- 申请日期:
- 1990.07.27
- 申请公布日期:
- 1993.01.12
- 申请人:
- BAYER AKTIENGESELLSCHAFT
- 发明人:
- MOHRS, KLAUS;RADDATZ, SIEGFRIED;FRUCHTMANN, ROMANIS;KOHLSDORFER, CHRISTIAN;MUELLER-PEDDINGHAUS, REINER;THEISEN-POPP, PIA
- 分类号:
- A61K31/47;A61K31/64;A61P3/02;A61P29/00;C07D215/14
- 主分类号:
- A61K31/47
- 摘要:
- Inhibiting leucotriene synthesis in patients with novel substituted N-(quinolin-2-yl-methoxy)benzylsulphonyl-urea of the formula <IMAGE> (I) in which A, B, D, E, G, K and M each independently is H, OH, halogen, CF3, OCF3, COOH, alkyl, alkoxy, alkoxycarbonyl or aryl, R1 is alkyl or cycloalkyl, R2 and R3 each independently is H or alkyl, and R4 is alkyl, aryl or a heterocyclic radical, and salts thereof.
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