Method of treating certain tumors using illudin analogs
- 申请公布号：
- US5439942(A)
- 申请号：
- US19900606511
- 申请日期：
- 1990.10.31
- 申请公布日期：
- 1995.08.08
- 申请人：
- THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 发明人：
- KELNER, MICHAEL J.;MCMORRIS, TREVOR C.;TAETLE, RAYMOND
- 分类号：
- A61K31/12;A61K31/215;A61K31/22;A61K31/27;A61P35/00;C07C45/45;C07C45/46;C07C45/65;C07C45/67;C07C49/665;C07C49/67;C07C49/683;C07C49/727;C07C49/737;C07C49/747;C07C49/753;C07C49/755;C07C69/007;C07C69/757;C07C271/12;(IPC1-7):A61K31/12
- 主分类号：
- A61K31/12
- 摘要：
- A method of inhibiting certain tumor cell growth in a subject is provided comprising contacting the tumor with a therapeutic amount of an illudin S or illudin M analog having the structure <IMAGE> wherein the analog is capable of inhibiting tumor cell growth without excessive toxicity to the subject and wherein R1 is hydrogen; R2 is methyl; and R3 is hydroxy.
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