Immunoactive peptides and antibodies and their use in anti-allergy treatment
- 申请公布号：
- IE71677(B1)
- 申请号：
- IE19900002154
- 申请日期：
- 1990.06.14
- 申请公布日期：
- 1997.02.26
- 申请人：
- BRITISH TECHNOLOGY GROUP LIMITED
- 发明人：
- STANWORTH DENIS RAYMOND;LEWIN IAN VICTOR;NAYYAR SARITA;JONES VALERIE
- 分类号：
- A61K38/00;A61K39/00;A61K39/35;A61K39/395;A61P37/08;C07K7/06;C07K14/52;C07K16/00;C07K16/06;C07K16/24;C07K16/42;C07K19/00;C12N5/10;C12N15/02;C12P21/08;C12R1/91;(IPC1-7):A61K39/395;C07K15/12
- 主分类号：
- A61K38/00
- 摘要：
- An immunogen comprising a residue of a histamine-releasing peptide comprising a cationic N-terminal head and a hydrophobic C-terminal tail, together with a residue capable of eliciting antibodies against said peptide whilst inhibiting histamine release by said peptide is useful in anti-allergy treatment. Preferably the histamine-releasing peptide is of formula: Lys-Thr-Lys-Gly-Ser-Gly-Phe-Phe-Val-Phe, optionally amidated at the C terminal. Antibodies to the histamine-releasing peptide are useful for passive immunisation.
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