TRANSFORMING GROWTH FACTOR ALPHA HIII

申请公布号：

WO9725349(A1)

申请号：

WO1996US00149

申请日期：

1996.01.04

申请公布日期：

1997.07.17

申请人：

HUMAN GENOME SCIENCES, INC.

发明人：

WEI, YING-FEI

分类号：

A61K38/00;A61K38/18;A61K48/00;C07K14/495;C12N5/00;C12N5/10;C12N15/00;C12N15/11;C12N15/19;C12N15/63

主分类号：

A61K38/00

摘要：

The present invention discloses transforming growth factor alpha HIII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptides and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.