POLYMERIC MICROBEADS AND METHOD OF PREPARATION

申请公布号：

EP0764047(A4)

申请号：

EP19950922150

申请日期：

1995.06.06

申请公布日期：

1998.01.07

申请人：

BIOPORE CORPORATION

发明人：

LI, NAI-HONG;BENSON, JAMES, R.;KITAGAWA, NAOTAKA

分类号：

A61K9/16;B01D15/08;B01J13/02;B01J13/14;B01J13/18;B01J13/20;B01J20/26;B01J20/28;B01J20/32;B01J39/26;B01J41/20;C07K1/04;C08F2/32;C08F8/00;C08F12/08;C08J3/16;C12N5/00;(IPC1-7):B01J13/02;B42F3/00;A61K9/64;B05D7/00;B05D1/40

主分类号：

A61K9/16

摘要：

The present invention relates to porous crosslinked polymeric microbeads having cavities joined by interconnecting pores wherein at least some of the cavities at the interior of each microbead communicate with the surface of the microbead. The present invention also relates to a process for producing a porous, crosslinked polymeric microbead as well as the product of this process. This process involves combining an oil phase with an aqueous discontinuous phase to form an emulsion, adding the emulsion to an aqueous suspension medium to form an oil-in-water suspension of dispersed emulsion droplets, and polymerizing the emulsion droplets to form microbeads. At least 10% of the microbeads produced in accordance with the present invention are substantially spherical or substantially ellipsoidal or a combination of the two.