AMINO ACID DERIVATIVE AND ANTI-ACTIVE OXYGEN AGENT

申请公布号：: JP2002173473(A)
申请号：: JP20010289068
申请日期：: 2001.09.21
申请公布日期：: 2002.06.21
申请人：: AJINOMOTO CO INC
发明人：: KITAZAWA MANABU;IWASAKI TAKAHARU
分类号：: C07D233/64;A61K8/02;A61K8/06;A61K8/49;A61K31/198;A61K31/255;A61K31/405;A61K31/4172;A61K31/4409;A61K31/4439;A61K38/00;A61P39/06;A61Q19/08;C07C215/56;C07C229/22;C07C229/24;C07C229/36;C07C237/12;C07C251/16;C07C279/14;C07C309/14;C07C309/16;C07C323/58;C07D209/20;C07D213/38;C07D401/12;C07K5/062;C07K5/072;(IPC1-7):C07C229/22;A61K7/00;A61K31/417;A61K31/440;A61K31/443
主分类号：: C07D233/64
摘要：: PROBLEM TO BE SOLVED: To provide a new anti-active oxygen agent capable of inhibiting active oxygen specifies generation, also having high safety and producible relatively at low cost. SOLUTION: This new anti-active oxygen agent comprises an amino acid derivative of the general formula (I) [wherein, Ar is 2-hydroxyphenyl, 2- hydroxy-1-naphthyl or pyridyl, in this case, the hydrogen atom(s) bound to the aromatic ring of each of the above groups may be substituted with halogen atom(s), alkyl, hydroxy, hydroxyalkyl, nitro, alkoxy or carboxy group(s); R is an amino acid side chain; X is -CH2-NH- or -CH=N-; Y is H, -COOR1, -SO3H, -CON(R2)R3, -CONHCH(R5)COOR4 or -CH2OH (wherein, R1 to R4 are each H or an alkyl; and R5 is an amino acid side chain); and n is an integer of 0 or 1] or a salt thereof as the active ingredient.