Methods for preparation of vaccines against cancer
- 申请公布号：
- US6410026(B1)
- 申请号：
- US19990360381
- 申请日期：
- 1999.07.23
- 申请公布日期：
- 2002.06.25
- 申请人：
- FORDHAM UNIVERSITY
- 发明人：
- SRIVASTAVA PRAMOD K.
- 分类号：
- C12N15/09;A23J1/00;C07H21/02;C07H21/04;C07K14/47;C12N1/15;C12N1/20;C12N5/10;C12N15/10;C12P21/00;C40B40/02;(IPC1-7):A61K38/00;A61K39/00;A61K35/12;C12N15/12
- 主分类号：
- C12N15/09
- 摘要：
- The present invention relates to methods for preparing immunogenic, prophylactically and therapeutically effective complexes of heat shock proteins noncovalently associated with antigenic peptides of cancer cells. The claimed methods comprise the constructing of a cDNA library from cancer or preneoplastic cell RNA, expressing the cDNA library in an appropriate host cell, and recovering the immunogenic complexes from the cells. Large amounts of such immunogenic complexes can be obtained by large-scale culturing of host cells containing the cDNA library. The complexes can be used as a vaccine to elicit specific immune responses against cancer or preneoplastic cells, and to treat or prevent cancer.
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