Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents
- 申请公布号：
- US2002120145(A1)
- 申请号：
- US20020092744
- 申请日期：
- 2002.03.07
- 申请公布日期：
- 2002.08.29
- 申请人：
- YANG BINGWEI V.
- 发明人：
- YANG BINGWEI V.
- 分类号：
- A61K;A61K31/47;A61K31/4704;A61K31/4709;A61P9/00;A61P9/10;A61P13/08;A61P17/06;A61P31/10;A61P31/12;A61P35/00;A61P35/02;A61P43/00;C07D;C07D215/00;C07D401/04;C07D401/06;C07D401/14;C07D409/14;(IPC1-7):A61K31/47;C07D215/20
- 主分类号：
- A61K
- 摘要：
- The present invention relates to compounds of formula 1 and pharmaceutically acceptable salts and solvates thereof wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and Z are as defined herein. The invention also relates to pharmaceutical compositions comprising compounds of formula 1 and to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering compounds of formula 1 to the mammal. The invention also relates to intermediates and methods useful in synthesizing compounds of formula 1.
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