METHOD OF DETECTING AMYLOID-CONTAINING LESIONS BY AUTOFLUORESCENCE

申请公布号：: CA2441104(A1)
申请号：: CA20022441104
申请日期：: 2002.03.14
申请公布日期：: 2002.09.26
申请人：: NYMOX CORPORATION
发明人：: DUPUIS, CELINE;AVERBACK, PAUL A.
分类号：: G01N33/58;G01N33/68;(IPC1-7):G01N33/48;A61B1/00;A61B5/00;A61K45/00;G01N21/62
主分类号：: G01N33/58
摘要：: Disclosed is a method of detecting amyloid-containing deposits in a mammal without administering exogenous chemicals such as fluorophores or chromophores. The method includes subjecting tissue of a mammal, preferably tissue of a mammal suspected of having at least one form of amyloidosis to autofluorescence-initiation, preferably by subjecting the tissue to at least excitation incident radiation from a light source having a wavelength of lig ht within the range of from about 360 to about 370 nm, and more preferably to illumination incident radiation from a light source having wavelengths in th e visible spectrum, to produce an emitted light signal beam and a reflected light signal beam. The method also preferably includes detecting the presenc e of emitted light having a wavelength of from about 400 nm to about 460 nm. T he method can be used to diagnose amyloidosis in living mammals using relativel y non-invasive imaging apparatus, and it can be used to monitor the efficacy o f treatment, or screen effective treatments for amyloidosis.