New camptothecin analogues, preparation methods thereof, use thereof as drugs, and pharmaceutical compositions containing them
- 申请公布号:
- EP1251125(A2)
- 申请号:
- EP20020077736
- 申请日期:
- 1996.06.21
- 申请公布日期:
- 2002.10.23
- 申请人:
- SOCIETE DE CONSEILS ET DE RECHERCHES D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
- 发明人:
- BIGG, DENNIS;LAVERGNE, OLIVIER;PLA RODAS, FRANCESC;POMMIER, JACQUES;ULIBARRI, GERARD
- 分类号:
- A61K31/47;A61K31/4745;A61K31/475;A61K31/496;A61K31/5377;A61P31/12;A61P33/00;A61P33/02;A61P35/00;A61P43/00;C07D209/00;C07D213/02;C07D213/61;C07D213/64;C07D213/66;C07D215/08;C07D221/00;C07D313/00;C07D413/10;C07D471/14;C07D487/04;C07D491/04;C07D491/044;C07D491/22;C07D498/14;(IPC1-7):C07D215/18
- 主分类号:
- A61K31/47
- 摘要:
- <p>Camptothecin analogues where the camptothecin hydroxy lactone is: (i) a beta -hydroxy lactone; or (ii) the corresp. beta -hydroxy acid resulting from ring-opening of the aforementioned lactone; or a (iii) deriv. of the beta -hydroxy acid in (ii) or its one of its salts. Also claimed are new industrial prods. of formula (M) and (A). R1 = lower alkyl, lower alkenyl, lower alkynyl, halo(lower alkyl), lower alkoxy(lower alkyl) or lower alkylthio(lower alkyl); R20 = H or halo; R22 = F, Cl, or lower alkoxy; R23 = prim. hydroxy-protecting gp.; and R18, R19 = H, halo, lower alkyl, lower alkoxy or OH.</p>
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