CHEMICAL MICRO-SENSOR

申请公布号：

WO2002101379(A2)

申请号：

US2002017125

申请日期：

2002.05.31

申请公布日期：

2002.12.19

摘要：

<p>An integrated optical capillary electrophoresis system for analyzing an analyte. A modulated optical pump beam impinges on an capillary containing the analyte/buffer solution which is separated by electrophoresis. The thermally-induced change in the index of refraction_of light in said electrophoresis capillary is monitored using an integrated micro-interferometer. The interferometer includes a first interferometer arm intersecting the electrophoresis capillary proximate the excitation beam and a second, referenceinterferometer arm. Changes in index of refraction in the analytemeasure by interrogating the interferometer state using white light interferometry and a phase-generated carrier demodulation technique. Background thermo-optical activity in the buffer solution is cancelled by splitting the pump beam and exciting pure buffer solution in a second section of capillary where it crosses the reference arm of the interferometer.</p>