METHODS FOR IDENTIFYING AGENTS THAT MODULATE MAST CELL DEGRANULATION
- 申请公布号：
- WO03074652(A2)
- 申请号：
- WO2003US03278
- 申请日期：
- 2003.02.04
- 申请公布日期：
- 2003.09.12
- 申请人：
- THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;F. HOFFMANN-LA ROCHE LTD.;WABL, MATTHIAS;JESSBERGER, ROLF
- 发明人：
- WABL, MATTHIAS;JESSBERGER, ROLF
- 分类号：
- G01N33/50
- 主分类号：
- G01N33/50
- 摘要：
- The invention provides screening methods to identify agents that modulate a level or an activity of a SWAP-70 protein in a degranulation competent cell; agents that reduce a level or an activity of a SWAP-70 protein, including agents identified by the screening methods; and pharmaceutical compositions comprising such agents. The present invention further provides methods of reducing degranulation in a degranulation competent cell, such as a mast cell or basophil. The methods generally involve reducing a level or activity of a SWAP-70 protein in a degranulation competent cell. The invention further provides methods of treating a mast cell-mediated disorder in an individual.
Copyright Notice © 2009-2024 传众 版权所有