Method for identifying compounds for treatment of insulin resistance
- 申请公布号：
- US6630312(B2)
- 申请号：
- US20010776432
- 申请日期：
- 2001.02.02
- 申请公布日期：
- 2003.10.07
- 申请人：
- JOSLIN DIABETES CENTER, INC.
- 发明人：
- SHOELSON STEVEN
- 分类号：
- A61K38/17;C12Q1/48;G01N33/68;(IPC1-7):G01N33/53;C12N11/00;A61K38/00
- 主分类号：
- A61K38/17
- 摘要：
- The invention features a method of identifying, evaluating or making a compound or agent, e.g., a candidate compound or agent, for treatment of a disorder characterized by insulin resistance. The method includes evaluating the ability of a compound or agent to bind IKK-beta or modulate IKK-beta activity, to thereby identify a compound or agent for the treatment of a disorder characterized by insulin resistance. The invention also features compounds for treating insulin resistance identified by such methods, and methods of treating a subject having a disorder characterized by insulin resistance by administering such agents.
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