METHOD, USE AND KIT FOR SEPARATING ALBUMIN FROM CONTAMINANTS IN A LIQUID
- 申请公布号：
- WO03097693(A1)
- 申请号：
- WO2003SE00792
- 申请日期：
- 2003.05.15
- 申请公布日期：
- 2003.11.27
- 申请人：
- AMERSHAM BIOSCIENCES AB;BELEW, MAKONNEN
- 发明人：
- BELEW, MAKONNEN
- 分类号：
- C07K14/765;(IPC1-7):C07K14/765;C07K1/18
- 主分类号：
- C07K14/765
- 摘要：
- The present invention is a method of separating recombinant human serum albumin (rHSA) from low molecular weight contaminants in a liquid, which method comprises the steps of: (a) providing a separation medium, which is comprised of anion-exchanging ligands coupled to a base matrix; and (b) contacting the liquid with the separation medium to adsorb the rHSA to the ligands. In one embodiment, the functional groups of the ligands are weak anion-exchanging groups, preferably secondary amines, and the density of ligands on the base matrix is relatively high.
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