Apparatus and method for detecting and locating rare cells

申请公布号：: US2004071332(A1)
申请号：: US20030616366
申请日期：: 2003.07.09
申请公布日期：: 2004.04.15
申请人：: XEROX CORPORATION
发明人：: BRUCE RICHARD H.;CURRY DOUGLAS N.;KRIVACIC ROBERT T.;HSIEH HUANGPIN B.
分类号：: G01N21/64;G01N15/00;G01N15/14;G01N21/27;G01N33/483;(IPC1-7):G06K9/00
主分类号：: G01N21/64
摘要：: In accordance with one aspect of the present application, an imager and method for detecting and locating rare cells in a sample is disclosed. An imager stage supports the sample. A fiber optic bundle has a proximate bundle end of first fiber ends arranged to define an input aperture viewing the sample on the translation stage. The fiber optic bundle further has a distal bundle end of second fiber ends arranged to define an output aperture shaped differently from the input aperture and disposed away from the imager stage. A scanning radiation source is arranged in fixed relative position to the input aperture. The scanning radiation source scans a radiation beam on the sample within a viewing area of the input aperture. The radiation beam interacts with the sample to produce a light signal that is reflected, scattered, transmitted, re-emitted, or otherwise collected and received by the input aperture and transmitted via the fiber optic bundle to the output aperture. The scanning radiation source rasters the radiation beam over a selected area of the sample. A photodetector is arranged to detect the light signal at the distal bundle end, and a processor processes the detected light signals.