Stable drug form for oral administration with benzimidazole derivatives as active ingredient and process for the preparation thereof
- 申请公布号：
- US2005064035(A1)
- 申请号：
- US20030665081
- 申请日期：
- 2003.09.16
- 申请公布日期：
- 2005.03.24
- 发明人：
- HEESE GERD-ULFERT;JUNGER HERBERT;LAICHER ARNIM;LORCK CLAUDIO;PROFITLICH THOMAS;WEISS GERD
- 分类号：
- A61K9/32;A61K9/36;A61K9/50;A61K9/58;A61K9/62;A61K31/4439;(IPC1-7):A61K31/443;A61K9/24
- 主分类号：
- A61K9/32
- 摘要：
- The invention relates to a stable medicament for oral administration which comprises (a) a core which contains an active ingredient selected from Omeprazole, Lansoprazole and Pantoprazole, together with customary pharmaceutical adjuvants, (b) an intermediate layer applied onto the core, and (c) a gastric juice-resistant outer layer. The intermediate layer in (b) is formed as a reactive layer in which a gastric juice-resistant polymer layer material partially neutralized with alkali with cation exchange capacity is present. Further, a method for the production of the stable medicament is disclosed.
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