NEW DERIVATIVES OF 6-(4-PHENYLBUTOXY)HEXYLAMINE AND PROCESS FOR PRODUCING SALMETEROL

申请公布号：: CA2344647(C)
申请号：: CA19992344647
申请日期：: 1999.09.20
申请公布日期：: 2005.07.05
申请人：: VITA-INVEST, S.A.
发明人：: MARQUILLAS OLONDRIZ, FRANCISCO;BESSA BELLMUNT, JORDI;DALMASES BARJOAN, PERE
分类号：: C07B61/00;C07C213/02;C07C213/08;C07C217/10;C07C217/28;C07C217/40;C07C217/42;C07C221/00;C07C223/02;C07C271/16;C07C271/18;C07D319/08;(IPC1-7):C07C217/44;A61K31/357;A61K31/135;C07D319/06
主分类号：: C07B61/00
摘要：: <p>The present invention refers to new derivatives of the 6- (9-phenylbutoxy)hexylamine of the general formula (I): (see formula I) wherein: ~ R1 is CHO or CHOR3OR4, where R3 and R4 independently are C1-C6 alkyl, aralkyl, or they form 5 or 6 membered cyclic acetals; and ~ R2 is H, benzyl or an alkyloxycarbonyl, aryloxy- carbonyl, aralkyloxycarbonyl or acyl group: and to a process for its obtention. The invention also refers to a new process for obtaining Salmeterol or its pharmaceutically acceptable salts, characterised in that reaction of an organometallic compound of the general formula (13) is carried out in an inert solvent at low temperature with a synthetic intermediate of the general formula (I) , wherein R1 is CHO, and R2 is an alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl or acyl group.</p>