A METHOD OF AUGMENTING GLUT4 PHOSPHORYLATION AND TRANSLOCATION FOR ENHANCING INSULIN SIGNAL

申请公布号：: WO2005074958(A2)
申请号：: WO2004IB04273
申请日期：: 2004.12.27
申请公布日期：: 2005.08.18
申请人：: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH;BHATTACHARYA, SAMIR;DEY, DEBLEENA;MANDAL, SWAPAN, KUMAR;MUKHERJEE, MOHUA;PAL, BIKASH, CHANDRA;BISWAS, TANUSHREE;DATTA, MALABIKA;ROY, SIB, SANKAR;BANDYOPADHYAY, ARUN;BANDOPADHYAY, SANTU;KONAR, ADITYA;GIRI, BIR, BHANU
发明人：: BHATTACHARYA, SAMIR;DEY, DEBLEENA;MANDAL, SWAPAN, KUMAR;MUKHERJEE, MOHUA;PAL, BIKASH, CHANDRA;BISWAS, TANUSHREE;DATTA, MALABIKA;ROY, SIB, SANKAR;BANDYOPADHYAY, ARUN;BANDOPADHYAY, SANTU;KONAR, ADITYA;GIRI, BIR, BHANU
分类号：: A61K31/70;A61K36/488
主分类号：: A61K31/70
摘要：: The present invention relates to a method of preventing and/or treating diabetes type 2, also, it relates to a method of augmenting Glut4 phosphorylation and Glut4 translocation to a target cell membrane to enhance insulin signal in a signal transduction pathway; further, it relates to a simplified and inexpensive process of obtaining extract and thereafter selectively, its active n-butanol fraction and active molecule Lupinoside PA (LPA4), useful in preventing and/or treating diabetes type 2; and lastly, a pharmaceutical composition thereof.