Carboline derivatives useful in the treatment of cancer
- 申请公布号：
- US2005282849(A1)
- 申请号：
- US20050107783
- 申请日期：
- 2005.04.18
- 申请公布日期：
- 2005.12.22
- 申请人：
- MOON YOUNG-CHOON;CAO LIANGXIAN;TAMILARASU NADARAJAN;QI HONGYAN;CHOI SOONGYU;LENNOX WILLIAM J;CORSON DONALD T;HWANG SEONGWOO;DAVIS THOMAS
- 发明人：
- MOON YOUNG-CHOON;CAO LIANGXIAN;TAMILARASU NADARAJAN;QI HONGYAN;CHOI SOONGYU;LENNOX WILLIAM J.;CORSON DONALD T.;HWANG SEONGWOO;DAVIS THOMAS
- 分类号：
- A61K31/4745;A61K31/724;(IPC1-7):A61K31/724;A61K31/474
- 主分类号：
- A61K31/4745
- 摘要：
- In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
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