2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF ß-SECRETASE (BACE)
- 申请公布号：
- WO2007092854(A2)
- 申请号：
- WO2007US61704
- 申请日期：
- 2007.02.06
- 申请公布日期：
- 2007.08.16
- 申请人：
- JANSSEN PHARMACEUTICA N.V.;BAXTER, ELLEN;REITZ, ALLEN B.;HUANG, YIFANG;CREIGHTON, CHRISTOPHER JOHN;MAHAROOF, UMAR SAIBU MOHOMED;REYNOLDS, CHARLES H.;LUO, CHI;TOUNGE, BRETT A.;ROSS, TINA MORGAN;LU, TIANBAO
- 发明人：
- BAXTER, ELLEN;REITZ, ALLEN B.;HUANG, YIFANG;CREIGHTON, CHRISTOPHER JOHN;MAHAROOF, UMAR SAIBU MOHOMED;REYNOLDS, CHARLES H.;LUO, CHI;TOUNGE, BRETT A.;ROSS, TINA MORGAN;LU, TIANBAO
- 摘要：
- The present invention is directed to 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of b-secretase, also known as b-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
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