METHOD OF ASSESSING COLORECTAL CANCER FROM A STOOL SAMPLE BY USE OF THE MARKER COMBINATION CALPROTECTIN AND HEMOGLOBIN/HAPTOGLOBIN COMPLEX

申请公布号：: EP2212700(A1)
申请号：: EP20080851789
申请日期：: 2008.11.18
申请公布日期：: 2010.08.04
申请人：: ROCHE DIAGNOSTICS GMBH;F.HOFFMANN-LA ROCHE AG
发明人：: KARL, JOHANN;GARCZAREK, URSULA;WILD, NORBERT
分类号：: G01N33/574
主分类号：: G01N33/574
摘要：: <p>The present invention relates to a method aiding in the assessment of colorectal cancer. The method especially is used in assessing the absence or presence of colorectal cancer in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a stool sample the concentration of the hemoglobin/haptoglobin complex and calprotectin and correlating the concentrations determined to the absence or presence of colorectal cancer. To further improve the assessment of colorectal cancer based on a method of this invention the level of one or more additional marker may be determined together with the hemoglobin/haptoglobin complex and calprotectin in a stool sample and be correlated to the absence or presence of colorectal cancer. The invention also relates to the use of a marker panel comprising the hemoglobin/haptoglobin complex and calprotectin in the early diagnosis of colorectal cancer and it teaches a kit for performing the method of the invention.</p>