PROCESS FOR THE PRODUCTION OF 2-[4-(3- OR 2-FLUOROBENZYLOXY)BENZYLAMINO]PROPANAMIDES WITH HIGH PURITY DEGREE
- 申请公布号：
- EP2229351(A1)
- 申请号：
- EP20080860373
- 申请日期：
- 2008.12.01
- 申请公布日期：
- 2010.09.22
- 申请人：
- NEWRON PHARMACEUTICALS S.P.A.
- 发明人：
- BARBANTI, ELENA;FARAVELLI, LAURA;SALVATI, PATRICIA;CANEVOTTI, RENATO;PONZINI, FRANCESCO
- 分类号：
- C07C231/12;A61K31/165;A61P25/00;C07C237/08;C07C251/24
- 主分类号：
- C07C231/12
- 摘要：
- A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]-propanamides and their salts with pharmaceutically acceptable acids with a high degree of purity, i.e. with a content of dibenzyl derivatives impurities lower than 0.03% by weight. The process is carried out by submitting a Schiff base intermediate to a reduction reaction with a reducing agent in an amount of organic solvent to allow the formation (and presence during a substantial portion of the reduction reaction) of a suspension of the Schiff base.
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