Cyanide-Tolerant Nitrile Hydratases

申请公布号：

US2010261250(A1)

申请号：

US20090539804

申请日期：

2009.08.12

申请公布日期：

2010.10.14

申请人：

OSSWALD STEFFEN;WECKBECKER CHRISTOPH;HUTHMACHER KLAUS;GERASIMOVA TATIJANA;NOVIKOV ANDREY;RYABCHENKO LUDMILA;YANENKO ALEXANDER;EGOROVA KSENIA

发明人：

OSSWALD STEFFEN;WECKBECKER CHRISTOPH;HUTHMACHER KLAUS;GERASIMOVA TATIJANA;NOVIKOV ANDREY;RYABCHENKO LUDMILA;YANENKO ALEXANDER;EGOROVA KSENIA

分类号：

C12N9/14;C07H21/00;C07H21/04;C07K14/00;C07K14/21;C12N1/20;C12N1/21;C12N9/88;C12N15/00;C12P13/02

主分类号：

C12N9/14

摘要：

Disclosed herein are cyanide-tolerant nitrile hydratases especially from Pseudomonas putida or Pseudomonas marginalis strains which exhibit increased cyanide tolerance. Also disclosed are methods of preparing amides from nitriles in the presence of cyanides and polynucleotide sequences coding for cyanide-tolerant nitrile hydratases.