DELTA-5 DESATURASE AND USES THEREOF

申请公布号：

US2011003351(A1)

申请号：

US20100878788

申请日期：

2010.09.09

申请公布日期：

2011.01.06

申请人：

ABBOTT LABORATORIES

发明人：

MUKERJI PRADIP;HUANG YUNG-SHENG;DAS TAPAS;THURMOND JENNIFER;PEREIRA SUZETTE L.

分类号：

A01H5/00;C12P7/64;A61K31/232;A61P3/00;A61P3/10;A61P9/10;A61P11/06;A61P13/12;A61P17/02;A61P17/06;A61P17/14;A61P17/16;A61P19/02;A61P19/10;A61P29/00;A61P35/00;C07H21/04;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/02;C12N15/09;C12N15/63;C12N15/82

主分类号：

A01H5/00

摘要：

The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “&Dgr;5-desaturase”) and at carbon 6 (i.e., “&Dgr;6-desaturase”) and to uses thereof. In particular, &Dgr;5-desaturase may be utilized, for example, in the conversion of dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to γ-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.