Microfluidic Cell Capture on Micro-Corrugated Surface
- 申请公布号：
- GB2472927(B)
- 申请号：
- GB20100017732
- 申请日期：
- 2006.04.05
- 申请公布日期：
- 2011.05.04
- 申请人：
- THE GENERAL HOSPITAL CORPORATION;CELLPOINT DIAGNOSTICS, INC.;LIVING MICROSYSTEMS, INC.
- 发明人：
- MARTIN FUCHS;MEHMET TONER;YING-XIN WANG;YI-SHUIAN HUANG;NEIL X KRUEGER;LOTIEN RICHARD HUANG
- 分类号：
- G01N33/50;B01L3/00;C12N5/00;G01N33/483;G01N33/543
- 主分类号：
- G01N33/50
- 摘要：
- A microfluidic device comprises a microfluidic channel having an inlet, an outlet and a at least one (or preferably two) micro-corrugated surface(s) wherein at least one surface of said channel comprises at least one capture moiety (e.g. anti-EpCAM antibody) that selectively captures a cell a sample. The device may be transparent such that it is suitable for use with a microscope or spectrometer. Devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles based on the size, shape or properties of the cells to be detected. Further methods for the diagnosis of cancer are disclosed.
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