ANIMAL MODELS AND THERAPEUTIC MOLECULES

申请公布号：

US2012167237(A1)

申请号：

US201213416684

申请日期：

2012.03.09

申请公布日期：

2012.06.28

申请人：

BRADLEY ALLAN;LEE E-CHIANG;LIANG QI;WANG WEI;LEGENT ANAIS;KIRBY IAN;KYMAB LIMITED

发明人：

BRADLEY ALLAN;LEE E-CHIANG;LIANG QI;WANG WEI;LEGENT ANAIS;KIRBY IAN

分类号：

A01K67/027;C07K16/00;C12N5/10;C12N15/13;C12N15/85

主分类号：

A01K67/027

摘要：

The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.