HETEROARYL PYRIDONE AND AZA-PYRIDONE AMIDE COMPOUNDS
- 申请公布号：
- CA2912359(A1)
- 申请号：
- CA20142912359
- 申请日期：
- 2014.07.02
- 申请公布日期：
- 2015.01.08
- 申请人：
- F. HOFFMANN-LA ROCHE AG
- 发明人：
- CRAWFORD, JAMES JOHN;LEE, WENDY;YOUNG, WENDY B.
- 分类号：
- C07D401/14;A61K31/407;A61K31/4184;A61K31/4365;A61K31/437;A61K31/4985;A61K31/502;A61K31/5025;A61P35/00;A61P37/00;C07D401/10;C07D471/04;C07D471/14;C07D487/04;C07D495/04
- 主分类号：
- C07D401/14
- 摘要：
- <p>Heteroaryl pyridone and aza-pyridone amide compounds of Formula (I) are provided, and various substituents including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk, and for treating cancer and immune disorders such as inflammation mediated by Btk. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.</p>
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