POLYPEPTIDES WITH PERMEASE ACTIVITY

申请公布号：

WO2014195376(A3)

申请号：

WO2014EP61632

申请日期：

2014.06.04

申请公布日期：

2015.04.09

申请人：

DSM IP ASSETS B.V.

发明人：

KLAASSEN, PAUL;DE WAAL, PAULUS PETRUS;DE JONG, RENÉ MARCEL;DRIESSEN, ARNOLD JACOB MATTIEU;NIJLAND, JEROEN GERBEN;SHIN, HYUN YONG

分类号：

C07K14/395

主分类号：

C07K14/395

摘要：

The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 A3 and a side chain hydrophobicity of 10 to 100 ΔtR.