AROMATIC 1,4-DI-CARBOXYLAMIDES AND THEIR USE
- 申请公布号:
- KR20090087492(A)
- 申请号:
- KR20097013895
- 申请日期:
- 2007.12.11
- 申请公布日期:
- 2009.08.17
- 申请人:
- THE GENETICS COMPANY INC.
- 发明人:
- GARCIA GABRIEL;DARAM PIERRE;FROESCH BARBARA;LEMAILLET GUY;SCAPOZZA LEONARDO
- 分类号:
- C07D407/12;A61K31/444;A61P35/00;C07D401/14
- 主分类号:
- C07D407/12
- 摘要:
- The invention relates to novel compounds of formula (I) wherein X, Y, Z represent independently from one another C or N, n stands for 1, 2, 3, m is 0 or 1, p stands for 0 or an integer from 1 to 6, R1, R2 represent independently from one another hydrogen, a halogen atom, a hydroxyl group, a C1-C3 alkyl group and a C1-C3 alkoxy group, R3 represents, independently from one another if p is not 0, hydrogen, halogen, a C1-C5 linear or branched alkyl, a carboxylyl, a carbomethoxyl, carboethoxyl, a benzyl, an acyl, a hydroxyl, a C1-C4 linear or branched alkoxyl, a trifluoromethyl, a cyano, a morpholino, a 1,3-dioxolyl, an N-acetylamidyl or an amidoyl group, a saturated 5-8 membered ring, a heterocyclic ring, optionally substituted by a C1-C3 alkyl, a hydroxyl or a benzyl group, a C1-C6 alkylsulfonyl, a mono or disubstituted C1-C5 alkyl group, a branched or a cyclic amine, R6 is H or part of a alicyclic, heteroalicyclic ring system, if m is 0 then C represents CF3 or a branched or unbranched C1-C4 alkyl group, if m = 1 then C represents-CH2-O-,-CH2-,-CH2CH2-,-CH2CH2CH2-,-CH2(CH2)CH2-or denotes a chemical bond between N-C or C-C, the CONR6 group may be linked to C either via its carbon or via its nitrogen atom, CYC stands for a by R3 substituted or unsubstituted phenyl, pyridinyl, naphthyl, quinolinyl, isoquinolinyl, isoxaxolinyl, thiophenyl, 1,3,4-thiadiazazolidinyl, furanyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, morpholinyl, furanyl, cyclohexenyl, and chromen-2-on-yl and its use as a medicament for the treatment of cancer. ® KIPO & WIPO 2009
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