TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
- 申请公布号：
- WO2015143652(A8)
- 申请号：
- WO2014CN74143
- 申请日期：
- 2014.03.26
- 申请公布日期：
- 2015.12.10
- 申请人：
- MERCK SHARP & DOHME CORP.;MITCHELL, HELEN;FRALEY, MARK E.;COOKE, ANDREW J.;STUMP, CRAIG A.;BESHORE, DOUGLAS C.;MCCOMAS, CASEY C.;SCHIRRIPA, KATHY;MCWHERTER, MELODY;ZHANG, XU-FANG;MERCER, SWATI P.;MOORE, KEITH;LIU, CHUNGSING;MAO, QINGHAU
- 发明人：
- MITCHELL, HELEN;FRALEY, MARK E.;COOKE, ANDREW J.;STUMP, CRAIG A.;BESHORE, DOUGLAS C.;MCCOMAS, CASEY C.;SCHIRRIPA, KATHY;MCWHERTER, MELODY;ZHANG, XU-FANG;MERCER, SWATI P.;MOORE, KEITH;LIU, CHUNGSING;MAO, QINGHAU
- 分类号：
- C07D235/00;A61K31/16;A61P29/00;C07D263/52;C07D275/04;C07D277/60;C07D285/14;C07D291/08
- 主分类号：
- C07D235/00
- 摘要：
- <p>The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula(I) which are tropomyosin-related kinase(Trk)family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF)receptor TrkA.</p>
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