Sustained Release Aminopyridine Composition

申请公布号：

US2016081992(A1)

申请号：

US201514960126

申请日期：

2015.12.04

申请公布日期：

2016.03.24

申请人：

Alkermes Pharma Ireland Limited

发明人：

Cunningham Sean;Mulligan Seamus;Myers Michael

分类号：

A61K31/4409;A61K9/20

主分类号：

A61K31/4409

地址：

Dublin IE

摘要：

A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at least 12 hours, preferably 24 hours or more and the use of the composition to treat various neurological diseases.

主权项：

1. A sustained release tablet comprising: a sustained release matrix and an aminopyridine, said tablet exhibiting a release profile to obtain a Cmax:Cτ ratio in vivo of about 1.0 to about 3.5 and a predetermined CavSS.