Methods and compositions to reduce oxidative stress
- 申请公布号：
- US9579321(B2)
- 申请号：
- US201414535690
- 申请日期：
- 2014.11.07
- 申请公布日期：
- 2017.02.28
- 申请人：
- University of Massachusetts
- 发明人：
- Messina Louis M.
- 分类号：
- A61K31/00;A61K31/34;A61K31/495;C12P13/10;A61K31/519;A61K31/198;A61K31/375;A61K45/06;A61K48/00;A61K35/13
- 主分类号：
- A61K31/00
- 代理机构：
- Fish & Richardson P.C.
- 代理人：
- Fish & Richardson P.C.
- 地址：
- Boston MA US
- 摘要：
- The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. The invention also provides combination therapies that are useful to balance the oxidative microenvironment of cells in vivo or in vitro.
- 主权项：
- 1. A method of treating Peripheral Arterial Disease (PAD) in a subject, the method comprising identifying a subject who has PAD and administering to the subject active agents consisting of:
a. L-arginine, b. tetrahydrobiopterin, and c. ascorbic acid or ascorbate; wherein the ratio of (a):(b) is 1-30:1; and wherein the ratio of (b):(c) is 1:0.1-15.
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