Pharmacological active hydrazin derivatives and process for their preparation

申请公布号：: GR3021169(T3)
申请号：: GR19960402471T
申请日期：: 1996.09.26
申请公布日期：: 1996.12.31
申请人：: CIBA-GEIGY AG
发明人：: FAESSLER, ALEXANDER, DR.;BOLD, GUIDO, DR.;LANG, MARC, DR.;SCHNEIDER, PETER, DR.
分类号：: A61K31/165;A61K31/175;A61K31/18;A61K31/34;A61K31/341;A61K31/395;A61K31/41;A61K31/44;A61K31/4402;A61K31/4418;A61K31/47;A61K31/535;A61K31/5375;A61K31/54;A61K38/07;A61P31/18;C07C241/02;C07C243/12;C07C243/14;C07C243/18;C07C243/24;C07C243/34;C07C255/60;C07C255/66;C07C269/06;C07C271/12;C07C271/22;C07C281/02;C07C281/04;C07C303/40;C07C311/05;C07D213/36;C07D213/40;C07D213/56;C07D215/48;C07D257/04;C07D265/30;C07D295/12;C07D295/18;C07D295/182;C07D295/185;C07D295/20;C07D295/215;C07D307/12;C07K5/06;C07K5/103;(IPC1-7):C07C243/12
主分类号：: A61K31/165
摘要：: <p>The invention relates to compounds of the formula <IMAGE> in which R1 and R9 are, independently of one another, hydrogen, acyl, unsubstituted or substituted alkyl, alkenyl or alkynyl; heterocyclyl; sulpho, or sulphonyl which is substituted by unsubstituted or substituted alkyl, aryl, heterocyclyl, alkoxy, which is unsubstituted or substituted, or by aryloxy; sulphamoyl which is unsubstituted or substituted on the nitrogen; or phosphoryl which is substituted by one or two radicals selected independently of one another from unsubstituted or substituted alkyl, from unsubstituted or substituted cycloalkyl, from aryl, from hydroxyl, from unsubstituted or substituted alkoxy, from cycloalkoxy and from aryloxy, with the proviso that not more than one of the radicals R1 and R9 is hydrogen; and R2 and R8 are each, independently of one another, hydrogen or one of the radicals mentioned above for R1 and R9; or the pairs of substituents R1 and R2 or R8 and R9 can each, independently of one another, form together with the nitrogen atom to which they are bonded certain heterocyclic rings; R3 and R4 are, independently of one another, hydrogen, unsubstituted or substituted alkyl or cycloalkyl; aryl; heterocyclyl; or unsubstituted or substituted alkenyl; or R3 and R4 together are unsubstituted or substituted alkylene, alkylidene or benzo-fused alkylene; R5 is hydroxyl; R6 is hydrogen; or R5 and R6 together are oxo; and R7 is unsubstituted or substituted alkyl or cycloalkyl; aryl; heterocyclyl; or unsubstituted or substituted alkenyl; as well as the salts of the said compounds where salt-forming groups are present, furthermore process for the preparation thereof, pharmaceutical products, the use as pharmaceutical composition or for the preparation of pharmaceutical products, as well as intermediates for the preparation of these compounds.</p>