OPHTHALMIC NANOPARTICULATE FORMULATION OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR
- 申请公布号：
- WO2006062875(A1)
- 申请号：
- WO2005US43858
- 申请日期：
- 2005.12.05
- 申请公布日期：
- 2006.06.15
- 申请人：
- MERCK & CO., INC.;PANMAI, SANTIPHARP;ALANI, LAMAN, L.
- 发明人：
- PANMAI, SANTIPHARP;ALANI, LAMAN, L.
- 分类号：
- A61K31/415
- 主分类号：
- A61K31/415
- 摘要：
- <p>The present invention is directed to a novel pharmaceutical composition suitable for ophthalmic use comprising nanoparticles dispersed in a liquid dispersion medium, wherein said nanoparticles comprise a cyclooxygenase-2 selective inhibitor having adsorbed on the surface thereof at least one surface stabilizer. The ophthalmic formulation of the present invention is stable, non-irritating and sufficiently bioavailable. The invention also encompasses a process for making as well as a kit for preparing the novel ophthalmic formulation.</p>
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