METHOD OF PARTIAL RESTORATION OF FUNCTIONAL ACTIVITY OF NEURAL NETWORKS IN VITRO IN CONDITIONS OF CONSIDERABLE DAMAGE

申请公布号：: RU2594065(C1)
申请号：: RU20150126394
申请日期：: 2015.07.01
申请公布日期：: 2016.08.10
申请人：: federalnoe gosudarstvennoe avtonomnoe obrazovatelnoe uchrezhdenie vysshego obrazovaniya "Nizhegorodskij gosudarstvennyj universitet im. N.I. Lobachevskogo"
发明人：: Vedunova Mariya Valerevna;Mishshenko Tatyana Aleksandrovna;Mitroshina Elena Vladimirovna;SHishkina Tatyana Viktorovna;Mukhina Irina Vasilevna
分类号：: A61K38/16;A61P25/00
主分类号：: A61K38/16
摘要：: FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to neurobiology, and can be used for partial restoration of activity of neural networks in vitro after death of a part functionally significant neurons under the influence of stress factors. For this purpose, in the remote post-traumatic period for 12 days, the injured neural culture of dissociated cells hippocampus at considerable damage of not more than 80 % of the above cells under conditions excluding the possibility of their spontaneous regeneration is exposed to neurotrophic factor of the brain factor of the brain.EFFECT: method enables partial recovering functional activity of neural networks in biological safety, simplicity and availability.3 cl, 3 dwg, 2 ex