RECOMBINANT ACTIVE HUMAN ZONA PELLUCIDA PROTEIN 3 (HZP3)
- 申请公布号：
- CA2321196(A1)
- 申请号：
- CA19992321196
- 申请日期：
- 1999.02.19
- 申请公布日期：
- 1999.08.26
- 申请人：
- EASTERN VIRGINIA MEDICAL SCHOOL
- 发明人：
- DONG, KE-WEN;OEHNINGER, SERGIO;GIBBONS, WILLIAM E.
- 分类号：
- G01N33/50;C07K14/705;C12N5/10;C12N15/09;C12N15/12;C12P21/02;(IPC1-7):C12N15/12
- 主分类号：
- G01N33/50
- 摘要：
- The invention relates to methods for producing recombinant human zona pellucida protein ("rhZP3") and glycosylated peptide having biological activity of binding to human spermatozoa. A human ovarian cell line is used to produce rhZP3 having a glycosylation pattern required for full biological activity. Methods of determining useful peptides with binding activity for human sperm and their syntheses, as well as using such peptides and proteins in therapeutics and diagnostics are discussed.
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