IMPROVED METHODS OF PRODUCING RPE CELLS AND COMPOSITIONS OF RPE CELLS
- 申请公布号：
- CA2702386(A1)
- 申请号：
- CA20082702386
- 申请日期：
- 2008.10.10
- 申请公布日期：
- 2009.04.23
- 申请人：
- ADVANCED CELL TECHNOLOGY, INC.
- 发明人：
- MALCUIT, CHRISTOPHER;LEMIEUX, LINDA;HOLMES, WILLLIAM;HUERTAS, PEDRO;VILNER, LUCY
- 分类号：
- C12N5/02;C12N5/071
- 主分类号：
- C12N5/02
- 摘要：
- <p>The present invention provides improved methods for producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The invention also relates to human retinal pigmented epithelial cells derived from human embryonic stem cells or other human multipotent or pluripotent stem cells. hRPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The hRPE cells described herein are useful for treating retinal degenerative diseases.</p>
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