VERFAHREN UND ZUSAMMENSETZUNG ZUR VERZÖGERTEN FREIGABE VON BIOLOGISCH WIRKSAMEN WIRKSTOFFEN.
- 申请公布号：
- DE69015212(T2)
- 申请号：
- DE1990615212T
- 申请日期：
- 1990.11.21
- 申请公布日期：
- 1995.05.04
- 申请人：
- AKTIESELSKABET DUMEX (DUMEX LTD.), KOPENHAGEN/KOEBENHAVN, DK
- 发明人：
- LADING, PIA, DK-2820 GENTOFTE, DK;LUNDSHOLM, YVONNE, S-230 30 OXIE, SE;NORLING, TOMAS, DK-2100 COPENHAGEN, DK
- 分类号：
- A61K9/00;A61K9/127;A61K9/22;A61K31/415;A61K47/14;A61K47/44;A61P1/02
- 主分类号：
- A61K9/00
- 摘要：
- Controlled delivery of biologically active agents such as pharmaceuticals to body sites is accomplished by combination with a monoglyceride and a vegetable oil. Upon contact with an aqueous liquid, the composition forms a reverse hexagonal liquid crystalline phase matrix which releases the active agent in controlled fashion. The method of delivery is particularly useful for the treatment of periodontal disease by insertion of the liquid crystalline phase precursor composition directly into the periodontal pocket, where water from the gingival fluid induces the spontaneous in situ formation of the reverse hexagonal liquid crystalline phase matrix.
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